Leptolide, a new furanocembranolide diterpene from Leptogorgia alba.
نویسندگان
چکیده
Six furanocembranolides (1-6) and one pseudopterolide (7) have been isolated from the octocorals Leptogorgia alba and Leptogorgia rigida, collected on the Pacific coast of Panama. Compound 1, named leptolide, has a new structure closely related to the neurotoxin lophotoxin (3). The X-ray structures of 1-3 were determined, and the absolute configurations of 2-7 are discussed. Compounds 1-7 were evaluated in vitro against drug-resistant Plasmodium falciparum.
منابع مشابه
Chloro-Furanocembranolides from Leptogorgia sp. Improve Pancreatic Beta-Cell Proliferation
Two new chloro-furanocembranolides (1, 2) and two new 1,4-diketo cembranolides (3, 4) were isolated from the crude extract of Leptogorgia sp. together with a new seco-furanocembranolide (5) and the known Z-deoxypukalide (6), rubifolide (7), scabrolide D (8) and epoxylophodione (9). Their structures were determined based on spectroscopic evidence. Four compounds: 1, 2, 7 and 8 were found to acti...
متن کاملLeptogorgia christiae (Octocorallia: Gorgoniidae) a new shallow water gorgonian from Pacific Panama
Leptogorgia christiae is a rarely collected new species found at 15–30 m depth at Roca Hacha, a rocky outcrop near Coiba Island characterized by its high diversity of octocorals. The branching pattern and combination of asymmetric blunt spindles, abundance of capstans, and a low occurrence of acute spindles are distinct characteristics of the new taxon. The new species is described, illustrated...
متن کاملSurvival, growth, and recruitment of octocoral species (Coelenterata: Octocorallia) in Coiba National Park, Pacific Panama
—Octocorals (order Alcyonacea) from the tropical eastern Pacific have been largely ignored in coral reef studies, with the exception of recent taxonomic reviews. This study is the first to examine the population dynamics of 10 shallow water species in six genera (Leptogorgia, Pacifigorgia, Muricea, Psammogorgia, Heterogorgia, and Carijoa) found in rocky coral communities in Coiba National Park,...
متن کاملLeptolide Improves Insulin Resistance in Diet-Induced Obese Mice
Type 2 diabetes (T2DM) is a complex disease linked to pancreatic beta-cell failure and insulin resistance. Current antidiabetic treatment regimens for T2DM include insulin sensitizers and insulin secretagogues. We have previously demonstrated that leptolide, a member of the furanocembranolides family, promotes pancreatic beta-cell proliferation in mice. Considering the beneficial effects of lep...
متن کاملAnti-tumor Activity and Cell Cycle Arrest of a New Diterpene Ester from Daphne mucronata Using K562 Cells
In our search for new anticancer medicinal plants, the antiproliferative activity of the methanol extract of Daphne mucronata (Thymelaeaceae) was evaluated using human myelogenous leukemia K562 cells. The cells responded to plant treatments in a dose dependent manner and the IC50 of the crude extract (equivalent to 1 g of plant leaves powder per ml) and the purified active component were found ...
متن کاملذخیره در منابع من
با ذخیره ی این منبع در منابع من، دسترسی به آن را برای استفاده های بعدی آسان تر کنید
برای دانلود متن کامل این مقاله و بیش از 32 میلیون مقاله دیگر ابتدا ثبت نام کنید
ثبت ناماگر عضو سایت هستید لطفا وارد حساب کاربری خود شوید
ورودعنوان ژورنال:
- Journal of natural products
دوره 68 4 شماره
صفحات -
تاریخ انتشار 2005